Ill. Staged Costly Enrollment Campaign; Calif. College Sign-Ups Exceed Expectations This is part of the KHN Morning Briefing, a summary of health policy coverage from major news organizations. Sign up for an email subscription. In health law implementation news, The Associated Press examines the $33 million that Illinois spent to promote enrollment. And a new California poll finds a significant drop in uninsured students at the California State University campuses.The Associated Press: Illinois Health Campaign Among CostliestPresident Barack Obama’s home state agreed to spend $33 million in federal money promoting his health care law, hiring a high-priced public relations firm for work that initially was mocked and spending far more per enrollee on television ads than any other large state. After getting a late start and facing intense pressure to avoid more embarrassment for the much-maligned law, Illinois officials last summer inked the most lavish contract in the history of FleishmanHillard’s Chicago office. The goal was getting uninsured residents to sign up for coverage. More than 90 people, including executives from the firm and its subcontractors, billed at least $270 an hour for salary and overhead during the first four months (Johnson, 6/12). Los Angeles Times: Share Of CSU Students Who Now Have Healthcare Exceeds ExpectationsDuring the open enrollment period that ended in April, some officials worried that if not enough young, healthy people signed up for coverage, insurance companies would be left with too many sick and expensive customers, which would eventually cause carriers to raise premiums. According to a poll released Thursday, at the 15 largest CSU campuses, approximately 30% of students were uninsured before enrollment began, and 10% were uninsured after. The drop accounts for 60,000 students who became insured, and illustrates the late surge of young people who signed up for policies (Karlamangla, 6/12).In Colorado -Denver Post: Decision To Allow Noncompliant ACA Plans Came Despite No Law ChangeLast fall, when President Barack Obama allowed states to extend policies that didn’t comply with the Affordable Care Act, Colorado Division of Insurance Commissioner Marguerite Salazar didn’t believe she had the authority under state law to make that change. Six months later, Salazar reversed that decision and allowed insurance companies a one-year extension through 2015. In March, Obama allowed states up to a two-year extension (Kane, 6/13).
While many other states are experiencing double-digit increases, California’s modest premium boost is viewed as good news for the health law. Los Angeles Times: Obamacare Premiums To Rise A Modest 4.2% In 2015Defying an industry trend of double-digit rate hikes, California officials said the more than 1.2 million consumers in the state-run Obamacare insurance exchange can expect modest price increases of 4.2% on average next year. On Thursday, Covered California announced the results of its negotiations with Anthem Blue Cross, Kaiser Permanente and other major insurers, an important yardstick for President Obama’s Affordable Care Act (Pfeifer, Terhune and Karlamangla, 7/31).The Wall Street Journal: California Sees Health-Law Premiums Rising 4.2% In 2015Premiums for health-law plans in California will go up 4.2% on average next year, an increase that the state’s insurance marketplace said was limited partly due to the large and relatively healthy pool of enrollees it had attracted. Nationally, 2015 rate changes for plans sold through marketplaces created under the Affordable Care Act will vary widely, with a mix of increases and some declines. But California is seen as a bellwether. According to federal statistics released May 1, the state had about 1.4 million of the 8 million total people who selected a marketplace plan during the open-enrollment period for 2014 coverage (Wilde Mathews, 7/31).Kaiser Health News: Good News On California ACA Rates. But Why?After years of double-digit rate hikes in health insurance premiums, California will see average increases of 4.2 percent in 2015 for people who purchase insurance through the Covered California exchange, the state’s Obamacare marketplace. … It’s good news for consumers, but two of the top insurance officials in the state disagree about why it’s happening. Covered California’s executive director and other analysts pointed to specific factors for this moderate increase. For starters, enrollment was very strong in 2014, more than a million people. In addition, healthy people signed up, spreading the risk. But the state’s insurance commissioner, Dave Jones, sees a different force in play. He believes that a statewide ballot measure, Proposition 45, has insurers scared (Aliferis, 8/1). The San Jose Mercury News: Obamacare: New California Rates Increase Only 4.2 PercentMost consumers who bought health care plans through Covered California, the state’s health-insurance exchange, will see low rate hikes in 2015, while some will see no increase or even a decrease, exchange officials said Thursday. The average California rate hike of the plans created by the nation’s health care law will be 4.2 percent, but some plans will offer average rates that are 8.5 percent lower. By comparison, state exchanges in Washington state and New York have reported average rate increases of 9.6 percent and 13 percent, respectively (Seipel, 7/31). Kaiser Health News: Capsules: Covered California Rates Up Modest 4.2 PercentCovered California says health care premiums will go up modestly for most people buying coverage on the state exchange next year by an average of 4.2 percent (Bartolone, 8/1).And in the news from Florida – Kaiser Health News: Florida’s Largest Health Insurer Is Raising Exchange Rates An Average Of 17.6 PercentFlorida Blue, the state’s largest health insurer, is increasing premiums by an average of 17.6 percent for its Affordable Care Act exchange plans next year, company officials say. The nonprofit Blue Cross and Blue Shield affiliate blames higher health costs as a result of attracting older adults this year who previously lacked coverage and are using more services than expected (Galewitz, 8/1). Going Against Trends, Covered California Premiums To Rise Just 4.2% In 2015 This is part of the KHN Morning Briefing, a summary of health policy coverage from major news organizations. Sign up for an email subscription.
Chris Fournier Twitter 20 Comments Canada’s currency began climbing immediately, rising 0.65 per cent to close at 0.75 cents to the U.S. dollar. Related Stories:Inflation eases (just enough) as Canadians pay less for gas and internetBank of Canada may diverge from dovish peers as economy reboundsU.S. underlying inflation stirring; labor market tighteningKey InsightsWednesday’s report bolsters the Bank of Canada’s view that the economy is emerging from a slowdown. It lends credence to Governor Stephen Poloz’s argument that interest rates will eventually need to move higher, even as his counterparts in the U.S. and Europe lean more towards rate cuts. The latest figures bring inflation above the central bank’s latest quarterly forecast. The central bank revised its 2019 outlook for CPI higher in April to 1.9 per cent, from 1.7 per cent previously. Kevin Carmichael: The idea that Canadians need oil and gas to make a living overlooks the data Drop in auto production leads surprise decline in Canada’s factory output Canada’s economy will have a sub-par year for growth, RBC forecasts Get MoreOn a monthly basis, the CPI increase was 0.4 per cent, matching April’s pace and topping the 0.1 per cent median forecast. CPI common core held at 1.8 per cent, median core climbed to 2.1 per cent and trim core accelerated to 2.3 per cent. The largest upside contributor to CPI on an annual basis was shelter costs, which rose 2.7 per cent. Food and transportation were also major drivers. Excluding gasoline, inflation climbed 2.7 per cent on the year. Bloomberg.com Reddit Facebook Recommended For YouGermany: Dry weather raises fears of forest fires, droughtGerman central bank expects feeble growth in second quarterDavid Rosenberg: Deflation is still the No. 1 threat to global economic stability — and central banks know itTrans Mountain construction work can go ahead as National Energy Board re-validates permitsBank of Canada drops mortgage stress test rate for first time since 2016 Join the conversation → Email Canadian inflation quickened in May on increases across all eight major components, giving the Bank of Canada plenty of scope to hold interest rates steady.The consumer price index jumped 2.4 per cent from a year earlier, compared with 2 per cent in April and versus a median economist forecast of 2.1 per cent, Statistics Canada said Wednesday from Ottawa. It was the highest annual rate since October, boosted by increases in food and durable goods prices.Core inflation, closely watched by policy makers, surged, with the average of the three key measures rising to 2.07 per cent, the highest since February 2012. Share this storyInflation surges to highest in seven years, giving Bank of Canada room to hold rates Tumblr Pinterest Google+ LinkedIn June 19, 20194:54 PM EDTLast UpdatedJune 20, 20197:25 AM EDT Filed under News Economy Inflation surges to highest in seven years, giving Bank of Canada room to hold rates Loonie climbs on the data Comment Bloomberg News More
Peugeot and Citroën develop all-electric commercial vehicles.PSA Group plans to offer electric versions of all of its commercial vehicles by 2025 and offer them at competitive prices compared to diesel counterparts.In 2020, the twin brands are expected to introduce Citroën Jumpy and Peugeot Expert, which would directly compete with Nissan e-NV200. Jumpy/Expert come in three versions with cargo volume between 4.6 and 6.6 m3 and payload of up to around 1,400 kg. The range of those BEVs is unknown at the moment, but PSA apparently targets 85% of applications.See Also Next-Gen Citroën C1, Peugeot 108 & Toyota Aygo Going Electric? Author Liberty Access TechnologiesPosted on October 20, 2018Categories Electric Vehicle News Source: Electric Vehicle News Another step will be to increase the range of Citroen Berlingo Electric and Peugeot Partner Electric, which since inception several years ago has been equipped with a 22.5 kWh battery. After Renault increased battery capacity of Kangoo Z.E. to 33 kWh, those two are not competitive.The final move would be electrification of bigger Citroën Jumper and Peugeot Boxer, based on the Fiat Ducato, so maybe even Fiat would consider electrification of Ducato on its side.Source: lesechos.fr, automobile-propre.com Peugeot e-LEGEND Concept: Paris Motor Show Video Roundup Paris: Peugeot Presents Plug-In Hybrid 508, 508 SW and 3008
BMW is taking its time to launch its next all-electric vehicle after the BMW i3, which was launched back in 2013, but they now say that they are ready to roll out more EVs.CEO Harald Krüger laid out the group’s electric vehicle plan in a speech in Munich on Wednesday. more…The post BMW lays out its latest electric vehicle plan appeared first on Electrek. Source: Charge Forward
Source: Charge Forward Ever since the ‘Dieselgate’ scandal, Volkswagen has been making a lot of claims about electrification, but it hasn’t much to show for yet.Now, CEO Herbert Diess makes one of the biggest electrification claims for the company yet: that they can produce 50 million electric cars and will have “much lower” prices than Tesla. more…The post VW claims it can produce 50 million electric cars, vows to have ‘much lower’ prices than Tesla appeared first on Electrek.
Source: Electric Vehicle News In November, Mitsubishi sold 299 Outlander PHEV in Canada (17.5% of total volume), while in the U.S. it was just 376 and 4.9% of the volume (3,735 and 3.4% for the 11-months).Tony Laframboise, president and CEO, Mitsubishi Motor Sales of Canada, Inc. said:“Canadians are recognizing that the Mitsubishi Outlander PHEV is electric and much more helping to establish a new industry high water mark. We see our strongest results in Québec month-after-month. Most Outlander PHEV customers were in gas-only SUVs and cars previously. As the first affordable plug-in hybrid SUV in the market, we’re helping to significantly grow adoption to EV. We are very proud of that,” Plug-In Electric Car Sales In Canada Keep Growing In October Mitsubishi Outlander PHEV is well suited for the Canadian market.Mitsubishi celebrates more than 5,000 Outlander PHEV sold in Canada during the first 11 month of the year, which makes the Japanese car the most popular plug-in hybrid on the market.Through 11 months, Mitsubishi delivered 5,052 Outlander PHEV, which is 21.4% of the total volume for the entire brand in Canada! The result is high thanks to a high ratio of 47% of dealers who decided to offer the plug-in hybrid.“Dealer support has been critical to Outlander PHEV success with wide availability of the vehicle from coast-to-coast. An outstanding 47 per cent of Outlander PHEV sales come from Québec. Top five Outlander PHEV dealers year-to-date in order are Québec Mitsubishi (Québec), Metrotown Mitsubishi (B.C.), St. Hyacinthe Mitsubishi (Québec), Wolfe Mitsubishi (B.C.) and Boisvert Mitsubishi (Québec).” Author Liberty Access TechnologiesPosted on December 4, 2018Categories Electric Vehicle News See Also Photo Caption:Mr. Serge McGraw from Québec helped Mitsubishi Outlander PHEV set a 5,000+ record as one of November’s Outlander customers purchased from top Outlander PHEV dealer Québec Mitsubishi. Mr. McGraw is moving out of a 2010 gas-only SUV and he chose Outlander PHEV for its load capacity and its ability to run on 100 per cent electric. He has driven his vehicle for three weeks already without filling the gas tank.(L-R) François Roy, General manager, Québec Mitsubishi, Serge McGraw, new owner of an Outlander PHEV, Marco Sauvageau, Sales Director, Québec Mitsubishi. Top 5 Electric Cars Of All-Time: Cumulative Sales Mitsubishi Won’t Do An Electric SUV: Committed To PHEVs
Get in on the full tax credit while it lastsThe Tesla end-of-year sales push is now truly on.More Tes;a Tax Credit Info UPDATE: Tesla: Allocation For Full U.S. Federal Tax Credit Sold Out Tesla Model 3 Sales Charge Way Past Milestone Of 100,000 In U.S. Final Chance To Order Tesla Model 3, S, X For Full Tax Credit Source: Electric Vehicle News Author Liberty Access TechnologiesPosted on December 20, 2018Categories Electric Vehicle News Several times now, Tesla or Elon Musk has called attention to the fact that the full $7,500 tax credit for Teslas is soon to enter the phaseout stage. However, now we’ve got an official announcement straight from the automaker.The difference here is that it’s a well-detailed explanation of the situation, the sales push (mainly applicable to the Tesla Model 3) and how it all works out. For example:To help ensure vehicles are available, we’ve released all our fleet vehicles – like those used for test drives – and vehicles where the original customer can’t take delivery by the end of the year.Grab a read in the full blog post from Tesla below:Full $7,500 Federal EV Tax Credit Expires in Under Two WeeksThe full $7,500 federal tax credit for Tesla customers ends in less than two weeks, and we’re doing everything we can to try to ensure those who order a vehicle today can take delivery by December 31st and take advantage of the savings. To help ensure vehicles are available, we’ve released all our fleet vehicles – like those used for test drives – and vehicles where the original customer can’t take delivery by the end of the year. Our mission is to accelerate the world’s transition to sustainable energy – and to do that, we need to get as many electric vehicles on the road as quickly as possible, which is why we are working around the clock to meet demand before the end of the year.In addition to the $7,500 tax credit, a number of states offer other electric vehicle incentives for customers. These, combined with the reduced costs of charging your Tesla versus paying for gasoline and a lower overall cost of ownership, result in significant savings for customers and mean our vehicles are even more affordable than some may realize. For example, after factoring in estimated gas savings and government incentives, the effective price of a new Model 3 mid-range Rear Wheel Drive in California is $31,700. In addition to the federal EV tax credit, here are some other state and local/utility incentives you may not be aware of:California offers a $2,500 state rebate, and PG&E offers an additional $800 rebate for applications submitted on or after January 1, 2019.Connecticut customers are eligible for a $2,000 rebate for new Model 3 RWD vehicles, as well as exemption from state emissions testing and a reduced vehicle registration fee.Massachusetts offers rebates up to $2,500 for new EV purchases.New York offers rebates up to $2,000.Colorado offers tax credits up to $5,000.Pennsylvania offers rebates up to $1,750.For the list of available state and local incentives and qualifications, visit https://www.tesla.com/support/incentives. To order a car online and take delivery by the end of the year, go to www.tesla.com or visit your nearest Tesla store for more information. You can order knowing that if you purchase a car without taking a test drive, you have three days to return it for a full refund.
In the last year we’ve seen electric scooters go from odd novelties to legitimate commuter vehicles. Companies like Bird and Lime are mostly to thank, offering cheap shared electric scooters that can be ridden for just a few dollars.But while shared electric scooters are often a cheaper and more fun way to get around than an Uber, a new Berkley study shows that owning an electric scooter may be better for you in the long run. more…The post New Berkley study on electric scooters shows it may be better to own than share appeared first on Electrek. Source: Charge Forward
The Chinese government claims a new technological breakthrough pushes lithium production prices to a record low, which could have a big effect on electric car battery costs. more…Subscribe to Electrek on YouTube for exclusive videos and subscribe to the podcast.https://youtu.be/ee5nKd7zjWoThe post China claims new breakthrough cuts lithium production costs to record low, EVs look to benefit appeared first on Electrek. Source: Charge Forward
Amazon offers the Greenworks 12A Corded Edger for $50.44 shipped. Regularly up to $80 at other retailers like Lowe’s, this is a new Amazon all-time low price. Take your lawn and garden to the next level with an electric edger. You’ll be able to skip the gas and oil here while easily trimming up the perimeter of your garden bed and walkways. Features include a 12A motor, adjustable handles and more. Rated 4/5 stars. Be sure to grab an extra outdoor extension cord to complete your setup. Head below for more Green Deals. more…Subscribe to Electrek on YouTube for exclusive videos and subscribe to the podcast.https://www.youtube.com/watch?v=V1zk7Eb8r-s&list=PL_Qf0A10763mA7Byw9ncZqxjke6Gjz0MtThe post Electric outdoor tools, solar panels, more in today’s best Green Deals appeared first on Electrek. Source: Charge Forward
Tesla is developing its own cells in-house at a “secret battery lab” as it prepares to launch its own battery cell manufacturing, according to a report. more…Subscribe to Electrek on YouTube for exclusive videos and subscribe to the podcast.https://www.youtube.com/watch?v=V1zk7Eb8r-s&list=PL_Qf0A10763mA7Byw9ncZqxjke6Gjz0MtThe post Tesla is developing its own cells in-house at ‘secret battery lab’, report says appeared first on Electrek. Source: Charge Forward
Sat 10 May 2008 06.26 EDT Manchester United Share on Pinterest Chelsea First published on Sat 10 May 2008 06.26 EDT · Chelsea manager says goals should not decide outcome· Blues focus on Bolton and hope for Wigan heroics Share on LinkedIn Grant was disappointed that Chelsea didn’t score more than six against Derby. Photograph: John Walton/Empics/PA Share on Twitter Share on Facebook Share on WhatsApp Share on Facebook @domfifield Chelsea Reuse this content Share on Messenger Shares00 Share via Email Share via Email Avram Grant said last night that Chelsea have been playing “the best football” over the Premier League run-in, though he conceded also that his side could end up losing the title on goal difference with the Israeli, albeit optimistically, suggesting the trophy should be decided in a play-off match if the top two finish level on points.Chelsea host Bolton Wanderers tomorrow conscious that Manchester United must drop points at Wigan if the London club are to stand any realistic chance of regaining the title given that they begin the day with a goal difference 17 worse than that of the league leaders. Grant has long been aware that such a gulf was effectively unbridgeable and insisted that a winner-takes-all play-off, a system used in Italy until two years ago, would be a fairer way of determining the champions.”Of course I have an interest in saying this now but I liked the system in Italy,” said Grant. “They played a play-off match if they were level and the title was decided like that. It is a better way, so ask the Premier League to change to this. Sometimes teams score more goals against the weaker sides and that is why their goal difference is better. When you miss as many as players as we did [through injury and the African Cup of Nations] the first target is just to win games.”I must say that United have played very good football this season and Alex Ferguson has said that he thinks this is his best season since he went there but in the end, if you end up with the same points, you are at the same level. We knew about the goal difference. I remember after the game against Derby County, which we won 6-1, saying to one of my players that I was disappointed because I wanted us to score more goals. He said: ‘Why do you say that? We’ve scored six.’ But I said it might be important at the end of the season. He came up to me last week and said: ‘How did you know?'”The odds still appear stacked against Chelsea claiming a third title in four seasons, yet there has been much to admire in their revival under Grant, particularly since the turn of the year. They are unbeaten in 20 league games and have secured a place in their first ever European Cup final in Moscow later this month.Grant, much maligned not least at times by the home supporters at Stamford Bridge, can justifiably survey the campaign with satisfaction and, having promised a more attack-minded approach upon taking up the reins last September, can even point to more entertaining displays in recent weeks.”We’ve been playing the best football in the last month, playing it at the right time in the season against really big teams and big managers,” he added. “Alex [Ferguson] said two or three months ago that this was the best United side he’d ever coached. If that’s so, we’ve given them a good battle and, if they take the title – and I’m not sure they will – it might be on goal difference. And that makes me very proud.”The doubts people had at the beginning were very reasonable but even a big coach has to be judged by his results. That’s how I want people to judge me and I think those results have been good. We’ve taken more points than any other team since I’ve been here. And we continue to develop. People called it ‘boring Chelsea’ before but I don’t think this team played boring football over the last three years. We wanted to go a different way, yes, but to use the good things we had and continue. Our first priority when I took over was to make history by reaching the final of the Champions League. But now we are here in the Premiership, we want to win this too.”We will know from the reaction of the fans what is happening at Wigan. Everybody will be watching that game – it’s more interesting, it’s in the spotlight. The pitch will be ready, Wigan will be ready, everything will be ready. They’ve fought hard at home and have not lost there this year, drawing with Arsenal and fighting to the last moment here against us. So let’s see what happens.” Dominic Fifield Grant calls for play-off to sort out title rivals Share on Twitter Topics
The Office of the Superintendent of Public Instruction wants your input to changes coming to Washington schools. The ESSA draft Consolidated Plan released Wednesday details how the state will implement the federal Every Student Succeeds Act.The plan is the result of months of work from hundreds of stakeholders across the state’s education sphere, including parents, teachers, districts statewide, tribal schools, professional education organizations, other state agencies and members of the Legislature.Comments will be collected, considered, and included in the Consolidated Plan when it is formally submitted to the U.S Department of Education. Public comment period opens November 16 and will run through December 15th.To learn more about the Consolidated plan and the provide public comment visit http://www.k12.wa.us/esea/essa/default.aspx.
The Washington State House recently released its $4.6 billion 2019-21 proposed capital budget. The capital budget proposal includes more than $54 million in funding for the 12th Legislative District projects. Highlights include:· $34 million for the replacement of Wells Hall at Wenatchee Valley College· $1.28 million for the Twisp Civic Building and Emergency Operation Center· $2 million for the Winthrop Library· $1 million for the Wenatchi Landing sewer extension· $400,000 for the Manson School District’s early learning facilities· $200,000 for the design of a substance use disorder facility in Chelan County· $52,000 for Heritage Senior Housing· $52,000 for revitalization in historic downtown ChelanRep. Mike Steele, R-Chelan and assistant ranking member of the House Capital Budget Committee commented on the proposed funding for projects in the 12th District:“I was thrilled to roll up my sleeves and assist in writing the state’s 2019-21 capital budget this year. Months of long and tough negotiating produced a bipartisan capital budget that will help fund significant improvements for our communities,” said Steele. “I’m incredibly grateful for all the work and time everyone put into the process. I’m also happy to see so many worthy projects listed in the proposal for the 12th Legislative District. It’s encouraging to see the millions of capital investments the House Capital Budget Committee greenlighted for our district’s continued economic expansion and job growth.”Rep. Keith Goehner, R-Dryden, issued the following statement:“This capital budget is a bipartisan proposal that would provide for the priorities and immediate needs of our state such as mental health and education,” said Goehner. “Although not all our of our requests were funded, it will also offer funding for much-needed infrastructure improvements and community projects in the 12th District and around Washington state.”The 105-day legislative session is scheduled to adjourn April 28.Reps. Mike Steele and Keith Goehner provided details for this story in a news release
Source:http://www.med.umich.edu/ May 10 2018Older Americans are often at a high risk for obstructive sleep apnea, yet this illness remains vastly underdiagnosed, a new study finds.University of Michigan researchers found evidence that more than half (56 percent) of persons ages 65 and older have a high risk of OSA, a sleep disorder in which the throat collapses during sleep, causing the patient to repeatedly stop breathing for periods of 10 seconds or longer throughout the night.But only 8 percent of these individuals have been tested for OSA, a disorder that is associated with significant health risks. An overnight sleep study is necessary to diagnose OSA.”It appears most older adults who are at risk for obstructive sleep apnea may not be getting referred for overnight sleep studies, and we may be missing an important chance for treatment,” says co-first author Tiffany Braley, M.D., M.S., assistant professor of neurology at Michigan Medicine.’Almost always confirmed’The data, published in the Journal of the American Geriatrics Society , come from 1,052 Medicare beneficiaries who completed a series of sleep questions and other surveys as part of the National Health and Aging Trends Study (NHATS). The NHATS sample is representative of more than seven million Americans.”We see that OSA was rarely evaluated, but when it was, it was almost always confirmed, as nearly all -; 94 percent -; of those at risk and tested for OSA were diagnosed,” says co-first author Galit Levi Dunietz, Ph.D., MPH, postdoctoral research fellow in sleep epidemiology at Michigan Medicine’s Sleep Disorders Center. “This suggests an opportunity to increase the evaluation among older Americans.”The NHATS survey questions about sleep resembled STOP-Bang, a popular questionnaire used in the clinical setting to evaluate common OSA risk factors. The survey evaluated whether respondents were at an advanced age, snored, were overweight, were male, had high blood pressure and felt fatigued.Among the 94 percent of those who received a diagnosis after being deemed at risk and given a sleep study, 82 percent of respondents’ physicians prescribed the first-line treatment. Continuous Positive Airway Pressure, or CPAP, sends pressurized air through the nose or nose and mouth to the throat, keeping it from collapsing during sleep.Related StoriesNew therapy shows promise in preventing brain damage after traumatic brain injuryDon’t ignore diastolic blood pressure values, say researchersNew method improves detection of atrial fibrillation in stroke survivors”It was good to see a high treatment rate after diagnosis, so the main concern is the underdiagnosis of OSA,” Dunietz says.More research needed”We know that OSA is quite common, yet often underdiagnosed in adults in the U.S.,” Braley says. “But most of the data available are from younger or middle-aged patients.”In the young and middle-aged populations, OSA is linked to significant health risks and can worsen quality of life. But in addition to a lack of data on the prevalence of OSA in the older population, Braley says more research is needed to confirm whether the consequences are the same for OSA in older adults.”This is an important first step in getting to the heart of question: What is the national scope of OSA, and our ability to recognize it, in all age groups?” she says. “If we can assume that older adults are subject to the same risks of OSA as middle-aged adults, then missing a diagnosis could ultimately lead to a higher risk of conditions like hypertension, stroke, heart disease, diabetes and depression, as well as cognitive impairment, which is especially important for older individuals. These conditions have serious impact, and lead to expensive medical care.”And some older patients may not realize their snoring, sleepiness, tiredness and other symptoms of OSA could be because of something other than normal aging. Those who are already dealing with health conditions such as obesity, diabetes, stroke, a previous heart attack and high blood pressure are more likely to experience OSA as well.”The results of this study are impressive,” says co-author Ronald Chervin, M.D., M.S., professor of neurology and director of the Sleep Disorders Centers at Michigan Medicine. “They amount to estimates, but even so, they help to quantify the magnitude of the challenge. “We already know that untreated sleep apnea costs billions each year, with decreased work productivity, impaired quality of life and increased medical costs. We still need to learn more about the impact of OSA in older persons more specifically, but the findings of this study suggest a huge, untapped opportunity to improve lives in older years, and perhaps medical costs as well, through more effective diagnosis, and then treatment, of OSA.”
May 21 2018A type of flavonoid found in dark-pigmented fruits like red grapes and blueberries may slow the lung function decline that occurs with aging, according to new research presented at the ATS 2018 International Conference.Previous research has shown that the plant-produced chemicals known as flavonoids have beneficial antioxidant and anti-inflammatory properties. Anthocyanins, the type of flavonoid investigated in the current study, have been detected in lung tissue shortly after being ingested, and in animals models of chronic obstructive pulmonary disease (COPD). The plant chemicals appear to reduce mucus and inflammatory secretions.However, “the epidemiological evidence on the association between flavonoids and lung function is very scant,” said lead study author Vanessa Garcia-Larsen, PhD, assistant professor in the Human Nutrition Division of the Department of International Health at the Johns Hopkins Bloomberg School of Public Health in Baltimore, Maryland. “So we wanted to investigate whether dietary intake and anthocyanins are associated with lung function decline in middle-age adults.”The researchers analyzed data from 463 adults (average age: 44) who participated in the second and third European Community Respiratory Health Surveys from 2002 to 2012. Those included in the current study completed a dietary questionnaire and underwent spirometry at enrollment and upon follow-up. A common lung function test, spirometry measures the amount of air that a person can forcefully exhale in one second (FEV1), the total amount of air a person can exhale after taking a deep breath (FVC) and the ratio of the two, FEV1/FVC. Participants were then grouped into quartiles based on the amount of anthocyanins they consumed.The study found individuals in the highest, compared to the lowest, quartile of anthocyanin intake had:Related StoriesPotential benefits and risks of using e-cigarettesFinancial incentives may help people quit smoking and remain smoke-freeNew research links “broken heart syndrome” to cancer a slower rate of annual decline in FEV1 than those in the lowest quartile: -9.8 milliliters per year (mL/yr) vs. -18.9 mL/yr. a slower rate of annual decline in FVC than those in the lowest quartile: -9.8 mL/yr vs. -22.2 mL/yr. a slower rate of annual decline in FEV1/FVC: -0.02/yr. Source:http://www.thoracic.org/ The researchers also analyzed the association between anthocyanin consumption and lung function in smokers, those who had never smoked and those who quit. The association between high consumption of the flavonoids and reduced lung function decline appeared to be stronger among both never smokers and those who had quit than in the general study population. Among smokers, the study did not find an association between anthocyanin intake and lung function.The study adjusted for a wide range of factors, including characteristics of participants’ diets, gender, height, body mass index and socioeconomic status. Another strength of the study was its inclusion of participants from two countries, Norway and England. The study was limited by its relatively small size and the fact that diets were self-reported.”Our study suggests that the general population could benefit from consuming more fruits rich in these flavonoids like berries, particularly those who have given up smoking or have never smoked, Dr. Larsen said. “For smokers, quitting remains the best thing they can do to protect their health.”The first European Community Respiratory Health Survey began in 1990 in response to a worldwide increase in asthma prevalence. The scope of the surveys has expanded to include information about the associations between behavioral and environmental factors that might also affect the development of COPD.
Source:https://www.clearabiotech.com/ Jul 6 2018Cleara Biotech B.V. (“Cleara”), a Netherlands-based biopharmaceutical company, announced today the creation of three public-private partnerships to discover and develop new therapeutics. Cleara has partnered with Dr. Peter de Keizer from the University Medical Center in Utrecht, Dr. Marco Demaria from the University Medical Center in Groningen, and Dr. Tobias Madl from the Medical University of Graz to engage in its discovery operations. Cleara’s initial funding was led by founding investor Apollo Ventures, a life sciences venture capital firm and company builder working across Europe and North America.Cleara is a preclinical R&D company engaged in the creation of therapeutics targeting the unique biology of senescent cells to treat age-related pathologies and therapy-resistant cancer. Senescent cells are rare cells that accumulate in our bodies as we age and contribute to the aging process. Removing these cells has been shown to reverse signs of aging including muscle and hair loss, cancer development, energy levels, and even increase healthy lifespan of mice.Related StoriesHow cell-free DNA can be targeted to prevent spread of tumorsResearchers use AI to develop early gastric cancer endoscopic diagnosis systemNew protein target for deadly ovarian cancerCellular senescence is a remarkably new field of study, and some of the world’s top senescent cell researchers have come together in Cleara to translate their scientific work on mice into human therapeutics. “These partnerships of top-notch academic institutions with drug development efforts will allow us to accelerate clinical development of our lead programs and provides an opportunity to treat multiple diseases by eliminating a patient’s senescent cells,” said Dr. de Keizer.”Senescent cells contribute to many different diseases of aging: muscle loss, kidney disease, heart disease, and even cancers,” said Dr. Demaria. “That’s why mice live longer and healthier when we eliminate their senescent cells, they stop dying of the diseases that they would otherwise suffer from.” The laboratories of de Keizer, Madl and Demaria received worldwide attention with results showing senescent cells are a source for therapy resistance in cancer and the development of the prospectively designed FOXO4-based anti-senescence drugs, which can effectively target signs of aging in mice. “We are excited to team-up within Cleara as this is a natural evolution of our aim to benefit mankind from the successes from years of fundamental research running in our academic labs.””Cleara scientists are the world leaders in advancing our understanding of the basic biology of senescent cells, and we have used that understanding to create the most potent and selective anti-senescence molecules yet discovered,” said Dr. James Peyer, Managing Partner of Apollo Ventures. “We are incredibly excited to advance the work at Cleara and our great institutional collaborators. Senescent cell elimination represents one of the most promising targets today in our fight against the diseases of aging.”
Aug 7 2018Seattle Children’s has opened a chimeric antigen receptor (CAR) T-cell immunotherapy trial for children and young adults with relapsed or refractory non-central nervous system EGFR-expressing solid tumors. In the phase 1 trial, STRIvE-01, cancer-fighting CAR T cells will target the EGFR protein expressed in many childhood sarcoma, kidney and neuroblastoma tumors.Solid tumors, excluding those of the brain, make up about 30 percent of all childhood cancers. Sarcoma, a cancer that develops in the bone and soft tissue; kidney malignancies, including Wilms tumor; and neuroblastoma, a tumor that forms in young nerve cells, are the most common types of non-central nervous system solid tumors diagnosed in children. Even as treatment advances have improved childhood cancer survival rates over the last several decades, these solid tumors remain among the most resistant to standard therapy when the cancer relapses or does not respond to initial treatment.”Despite employing modern treatments that offer more intensive therapy or new drug combinations for children with solid tumors, we’ve been unable to improve outcomes for our highest-risk patient groups,” said Dr. Katie Albert, an oncologist at Seattle Children’s and lead investigator for the STRIvE-01 trial. “It is those groups that push us to come up with innovative approaches so that we can see all of our patients cured of their cancer.”While CAR T cells engineered to fight cancer have shown promise for curing childhood leukemia in clinical trials at Seattle Children’s, solid tumors pose unique challenges. Solid tumors exist in protective microenvironments that help them evade the immune system, making it more difficult to keep the CAR T cells stimulated.”In order for this therapy to be effective against solid tumors and induce remission for our patients, we have to find a way to not only get the CAR T cells into the tumor microenvironment, but also ensure they can survive and thrive there,” said Albert.To construct the CAR T cells for STRIvE-01, researchers led by Dr. Mike Jensen at the Ben Towne Center for Childhood Cancer Research at Seattle Children’s Research Institute will reprogram a patient’s T cells to target the abnormal EGFR protein expressed on the surface of many solid tumor cancer cells. In normal tissues, EGFR is responsible for cell growth and development. When expressed in malignant solid tumors, EGFR has been associated with more aggressive and invasive growth.By arming the CAR T cells with an antibody known as EGFR806, researchers hope to selectively find and destroy solid tumor cells expressing EGFR with limited toxicity to normal tissues.As Albert explained, “Normal tissue, including skin, is enriched in EGFR, so it is advantageous to equip the CAR T cells with an antibody that recognizes EGFR on tumor cells and leaves healthy cells relatively protected.”Related StoriesStudy: Megakaryocytes play an important role in cell migrationComprehensive cell atlas of the human liverSlug serves as ‘command central’ for determining breast stem cell healthAnticipating that it will take a multi-faceted approach to overcome solid tumors, STRIvE-01 will include two sequential treatment arms. Children and young adults enrolled in the first arm will receive EGFR806 CAR T cells to first evaluate the toxicity and establish the maximum tolerated dose of the experimental therapy. Once the first arm is complete, the second arm will open. Patients in the second arm will receive CAR T cells reprogrammed to target both EGFR and CD19, a protein expressed on a subset of white blood cells called B lymphocytes.”By including a CAR T-cell therapy that targets two proteins, we’re a step ahead in addressing a known challenge with solid tumors – the cancer-fighting T cells won’t hang around long enough to get to the tumor tissues and keep the cancer from coming back,” said Albert. “Building on what we’ve learned in our trials for leukemia, our hope is that the secondary target of CD19 will constantly interact with B lymphocytes in the blood to promote the expansion and persistence of the EGFR-directed CAR T cells.”The study plans to enroll approximately 36 patients across both arms to assess the dosing, safety and tolerability of the CAR T-cell therapies. The results from STRIvE-01 will inform the clinical development of future CAR T-cell trials aimed at finding the most effective targets and therapeutic combinations for pediatric solid tumors.”We recognize that it will likely require a range of therapeutic strategies to manipulate the immune environment enough to cure patients with hard to treat solid tumors,” said Albert. “I’m excited to have the opportunity to incorporate our most advanced immunotherapy strategies into a solid tumor program that I hope will provide families the most effective and comprehensive CAR T-cell treatment options for their child’s cancer.”STRIvE-01 joins a robust pipeline of T-cell immunotherapy trials underway at Seattle Children’s focused on harnessing the immune system to offer better treatment options for children and young adults with cancer. Seattle Children’s is dedicated to improving CAR T-cell immunotherapy for a variety of childhood cancers to the point that it helps patients achieve long-term remission – and ultimately – a cure.The T-cell immunotherapy trials at Seattle Children’s are funded in part by Strong Against Cancer, a national philanthropic initiative with worldwide implications for potentially curing childhood cancers. If you are interested in supporting the advancement of immunotherapy and cancer research, please visit Strong Against Cancer’s donation page. Source:http://www.seattlechildrens.org